Rnf128 ring finger protein 128 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnf128provided by RGD
Official Full Name: ring finger protein 128provided by RGD
Primary source: RGD:1566282
See related: Ensembl:ENSRNOG00000055721 AllianceGenome:RGD:1566282
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566282
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in regulation of protein stability and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within negative regulation of cytokine production. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and late endosome. Orthologous to human RNF128 (ring finger protein 128). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 197.3), Liver (RPKM 154.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (107968973..108087037)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (103183643..103298431)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (110789061..110877964)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI987883 (e-PCR)
- UniSTS:181332

BI294846 (e-PCR)
- UniSTS:246143

RH128533 (e-PCR)
- UniSTS:211841

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF128

Names: ring finger protein 128, E3 ubiquitin protein ligase

NP_001166820.1

EC 2.3.2.27

EC 6.3.2.-

XP_008771641.1

EC 2.3.2.27

EC 6.3.2.-

XP_038955642.1

EC 2.3.2.27

EC 6.3.2.-

XP_038955643.1

EC 2.3.2.27

EC 6.3.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001173349.1 → NP_001166820.1 E3 ubiquitin-protein ligase RNF128 precursor

See identical proteins and their annotated locations for NP_001166820.1

Status: PROVISIONAL

Source sequence(s)

BC167061

UniProtKB/TrEMBL

B2RZ84

Related

ENSRNOP00000071530.1, ENSRNOT00000086308.2

Conserved Domains (2) summary

cd02122
Location:48 → 193

PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...

pfam13639
Location:275 → 318

zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

107968973..108087037

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008773419.4 → XP_008771641.1 E3 ubiquitin-protein ligase RNF128 isoform X1

See identical proteins and their annotated locations for XP_008771641.1

UniProtKB/TrEMBL

B1H231

Related

ENSRNOP00000068929.1

Conserved Domains (2) summary

cd02122
Location:34 → 167

PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...

pfam13639
Location:249 → 292

zf-RING_2; Ring finger domain
XM_039099714.2 → XP_038955642.1 E3 ubiquitin-protein ligase RNF128 isoform X2

Conserved Domains (3) summary

COG5243
Location:109 → 224

HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]

cd16802
Location:116 → 164

RING-H2_RNF128_like; RING finger, H2 subclass, found in RING finger protein 128 (RNF128) and similar proteins

cl28883
Location:3 → 34

PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
XM_039099715.2 → XP_038955643.1 E3 ubiquitin-protein ligase RNF128 isoform X3

Conserved Domains (3) summary

COG5243
Location:99 → 214

HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]

cd16802
Location:106 → 154

RING-H2_RNF128_like; RING finger, H2 subclass, found in RING finger protein 128 (RNF128) and similar proteins

cl28883
Location:1 → 24

PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...